Bupivacaine Impurity 30 CAS 852804-30-9(free base)
| CAS No. | 852804-30-9(free base) |
| Molecular Formula | C22H37N2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Bupivacaine Impurity 30 (CAS 852804-30-9(free base), C22H37N2OBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Bupivacaine Impurity 30 (C22H37N2OBr) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 425.45 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H37N2O Br |
| Molecular Weight | 425.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Bupivacaine Standards
- Bupivacaine EP Impurity D (CAS 1037184-07-8)
- Bupivacaine Impurity 44 (CAS 104485-01-0)
- Bupivacaine-D9 Hydrochloride (CAS 1286973-34-9)
- Bupivacaine EP Impurity E (CAS 1330172-81-0)
- Bupivacaine N-Oxide (CAS 1346597-81-6)
- Bupivacaine-d9 N-Oxide (CAS 1346598-03-5)
- Bupivacaine Hydrochloride (CAS 14252-80-3)
- Bupivacaine Impurity 20 (CAS 15116-13-9)
Recommended Standards
- Josamycin EP Impurity I (CAS 18361-47-2)
- Pranoprofen Impurity 24 (CAS CATO-C4X-181124)
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- tert-Butyl 3-(4-fluorophenyl)-3-hydroxyazetidine-1-carboxylate (CAS 958297-44-4)
- Olanzapine Impurity 25 (CAS 612503-08-9)
- 4-Methoxy-4-(trifluoromethyl)cyclohexane-1-carbaldehyde (CAS 1637310-72-5)
- 5-Methyl-[1,2,5]thiadiazolo[3,4-d]pyrimidin-7-amine (CAS 7248-53-5)
- 3,6-Dihydroxyanthracen-9(10H)-one (CAS 1998216-35-5)
- Lithium 3-(methoxymethyl)-1-methyl-1H-pyrazole-5-carboxylate (CAS 2460255-86-9)
- Neuropeptide S (rat) (CAS 412938-75-1)
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